Autologous Matrix-induced Chondrogenesis Help Repair Articular Cartilage Damage

 

Autologous matrix-induced chondrogenesis is used to treat articular cartilage damage with the combination of micro-fracture surgery and application of a bi-layer collagen I/III membrane. Currently, there are limited long-term benefits, as the potential benefits have not been documented and there is no evidence that autologous matrix-induced chondrogenesis improves arthritis pain or quality of life in patients with moderate to severe osteoarthritis.


 Osteoarthritis is the most common type of joint disease, which affects more than 32.5 million adults in the U.S. Moreover, it is the most common form of arthritis, affects around 8.75 million people (aged 45 and over) in the U.K., and up to 10% of the adult and 20% of the elderly population in Singapore. Furthermore, in Italy, the number of people affected by these chronic diseases went from 10.3 million individuals in 2010 to 9.8 million by the end of 2018.

Autologous matrix-induced chondrogenesis is considered minimally invasive and can be performed on patients with mild to moderate pain. The most common site of surgery is the knee. However, other sites such as the forearm, lower back, hip, ankle, and vertebrae may also be involved. For patients with arthritis, the procedure may require longer periods of hospitalization and prolonged postoperative care. The satisfactory outcome of autologous matrix-induced chondrogenesis is the fulfillment of a rigorous physical therapy program. Recommendations and guidelines exist, although they must adapt to the needs of individual patients.

Autologous matrix-induced chondrogenesis can be used in load-bearing joints, such as the hip, knee, and ankle. In conjunction with bone grafting, autologous matrix-induced chondrogenesis can also be used in cases where a lesion may involve the subchondral bone to a considerable depth, such as osteochondritis dissecans, a condition in which the bones below the cartilage dies due to lack of blood flow.

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