Hydroxychlorobenzene, Used For Treatment of Cirrhosis, Is a Major Chronic Liver Diseases Therapeutics

 

Chronic liver diseases therapeutics include, diuretic, ammonia reducers, beta blockers, antibiotics, and antiviral drugs. Acute hepatic porphyria, alagille syndrome, autoimmune hepatitis, biliary atresia, cirrhosis, and crigler-najjar syndrome are some of the main diseases of the liver. Chronic liver disease is ranked the twelfth leading cause of premature death in the United States. There was a significant 65% increase in deaths related to chronic liver disease from 1999 to 2021. The leading reason why people get cirrhosis is because they abuse alcohol, smoking, or use contaminated medications. The number one cause is alcoholic hepatitis, which is caused by hepatitis B and C virus infection.

The only treatment for cirrhosis is surgery. However, there are several types of non-surgical treatments. These treatments include non-pharmacological interventions like dietary modifications, weight loss, nutritional supplements, antioxidant supplementation and physical therapy. Popular cirrhosis drugs include, microzide (hydrochlorothiazide), Lasix (furosemide), Aldactone (spironolactone), chlorthalidone, Demadex (torsemide), Urso Forte (ursodiol), Ocaliva, Aldactazide (spironolactone / HCTZ), Diuril (chlorothiazide), and Edecrin (ethacrynic acid).


 

One of the most popular chronic liver diseases therapeutics is hydrochlorophane or hydroxychlorobenzene (HCA). It is used for the treatment of cirrhosis. This is a chemical compound derived from crude oil. The compound has been found to inhibit the formation of fats in the body by inhibiting fat synthesis. Clinical trials have shown that HCA slows down the progression of primary bile duct carcinoma (BDC) and decreases the chances of developing a form of BDC in the future.

However, despite its effectiveness in slowing the progress of BDC, research has shown that HCA does not prevent the progression of cirrhosis. The problem with HCA as a liver cirrhosis drug is that its effects wear off over time. For instance, a patient who has taken HCA for one year after being diagnosed with BDC will only experience minimal improvement. It is for this reason that most physicians recommend other treatments for the condition other than HCA. Among the other medicines in the liver cirrhosis drugs market are anti-inflammatory medications, immunosuppressants, herbal remedies and drugs to strengthen the immune system. In fact, the medicines to treat BDC are usually accompanied by anti-inflammatory and immune-modifying drugs.

Major players involved in development and commercialization of chronic liver diseases therapeutics are focused on acquiring new drugs. For instance, in December 2020, Gilead Sciences signed a definitive agreement to acquire German biotechnology company MYR for approximately US$ 1.4 billion in cash. With this deal, Gilead will acquire First-in-Class entry inhibitor Hepcludex (bulevirtide) for the treatment of chronic hepatitis delta virus (HDV), a severe form of viral hepatitis.


 

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