Autologous Stem Cell and Non-Stem Cell-Based Therapies Demonstrate Potential in Treatment of Neurodegenerative, Autoimmune, Cardiovascular, Cancer, Skin, and Infectious Diseases

 

The demand for autologous stem cell and non-stem cell-based therapies has witnessed significant rise in the recent past with high prevalence of various diseases. For instance, according to the World Health Organization’s Globocan 2020, Germany recorded 628,519 cases of cancer 252,065 cancer-related deaths in 2020. 


 

Autologous stem cell and non-stem cell-based therapies involve use of regenerative medicines for the treatment of neurodegenerative, autoimmune, cardiovascular, cancer, skin, and infectious diseases. Autologous transplant is a treatment where stem cells are taken from one person and transplanted into another person. This treatment can be used for treating different medical and health problems such as heart disease, cancer, neurological disease, strokes, and arthritis.

The potential benefit from using non-stem cell based therapy and autologous-platelet-rich plasma therapies lies in its ability to replace mature adipose tissue (fat) in patients with severe disease conditions such as cachexia and secondary obesity. The use of these treatments can also lead to improved quality of life in patients with advanced heart disease, type 2 diabetes, and liver disease. The potential applications of this treatment include the following: cachexia; secondary obesity; treatment of liver disease and hepatitis; and treatment of diseases that have no clearly defined treatment path. It has been shown that patients undergoing this therapy have a rapid onset of weight loss and an increase in lean body mass after surgery.

The potential benefits of autologous stem cell and non-stem cell-based therapies are being evaluated for possible use in the treatment of osteoarthritis. Autologous-platelet-rich-plasma therapy has been shown to be very effective in the treatment of osteoarthritis, particularly of the knee osteoarthritis. Patients in the studies that have used this therapy have experienced a rapid initiation of weight loss, a rapid decrease in their hip joint pain and swelling, and an improvement in their gait. If found to be safe and well-effective, this therapy may be an effective treatment for future patients with knee osteoarthritis. Moreover, increasing investment in such regenerative therapies is also expected to be impact its adoption. For instance, in February 2021, Cellino, a personalized regenerative medicine company, raised US$ 16 million.



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