Bioelectronics Find Application in Repair of Injuries By Means of Electrical Stimulation and in the Treatment of General Musculoskeletal/Soft-Tissue Pain

 

The field of bioelectronics has an impact on how we think about and treat the body, how medical professionals test medical specimens, and how drug research is conducted. Bioelectronics is in the process of rapidly advancing towards creating electronic medical equipment that could substitute all the traditional parts of an EKG or ultrasound machine. It has opened up new possibilities for the treatment and diagnosis of diseases through the identification and stimulation of biological systems.


 

Organic bioelectronics (OBOE) involves the study of organic materials used in electronic applications. Organic materials include sugars, metals, and organic compounds. They are used to develop and design new electronic systems based on these organic materials. OBOE have unique electrical properties and thus form an attractive platform for developing new electronic devices. OBOE are organic devices which are designed to couple a source of power with electronic signals produced by biological processes. OBOE are used in medical practices to enable testing of potential drugs before they are released into the environment. OBOE include biological probes such as bacteriocins, mycoheterones, and receptors of interest such as cancer cells. They also include molecular probes including antibodies, lectins, microtubules, and micro-encapsulated RNAs (diesterase inhibitors) and T-cells.

The study of organic bioelectronics is an important part of the field of chemical engineering. OBOE provides an opportunity for chemical engineers to integrate biologically inspired design principles with information processing systems. This integration provides opportunities to design and fabricate electronic devices based on biological activity. The ultimate goal of incorporating organic electronics with information processing systems is to build electronic devices that can function in the same way as living organisms do. This will lead to the creation of digital information processing systems.

The applications of organic bioelectronics are growing significantly in all the fields of medicine. It is used to provide electrical stimulation to promote cellular oxygenation and growth, to facilitate blood vessel expansion and contractions, and to facilitate cell metabolism. It is also being applied to repair the injury systems of injured patients by means of electrical stimulation and for the treatment of general musculoskeletal/soft-tissue pain. For instance, in November 2020, BioElectronics Corporation, the U.S.-based developer of non-invasive electroceuticals and disposable, drug-free, pain therapy devices, received the CE Mark for its ActiPatch and RecoveryRx Pulsed Shortwave Therapy (PSWT) medical devices.

Another field in which the field of bioelectronics has made significant advances is that of polymeric mixed conductor implant technologies. These technologies utilize non-porous, conductive polymer materials and biological components such as neurotransmitters, proteins, nucleic acids and enzymes to place implanted electronic signals in a specific location. This technology is currently used in the field of neurostimulation, application of energy and tissue repair. Polymeric mixed conductor implant technologies are developed using a two-phased approach, which involves first introducing the material into the targeted area and then implanting the signal generator. The resulting polymer structure allows for efficient, near-instantaneous fabrication of the engineered signal generators.

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