High Prevalence of Cancer and R&D of New Products to Boost Demand for Chromatography Instruments
Chromatography is a fundamental biophysical process that allows the separation and discrimination of the various components of a sample for quantitative and qualitative analysis. The separation of the main components based on their attributes and/or structure results in the separation of the analyte and its carrier, the molecules, and the environment.
Chromatography instruments include, autosampler, headspace autosampler, gas regulators, liquid chromatography (HPLC) analytical hplc system, ion chromatography instrument, gel permeation chromatograph / GPC system, and others. These instruments find application in life sciences, pharmaceuticals, nutrition, environmental, veterinary, forensic, and industrial applications.
High prevalence of cancer is expected to boost demand for these instruments. For instance, according to the World Health Organization’s Globocan 2018, Germany recorded 608,742 cases of cancer 247,462 cancer-related deaths in 2018. Such scenario has prompted R&D of new products. For instance, in June 2020, Agilent Technologies Inc. launched Agilent 6470B Triple Quadrupole LC/MS (6470 LC/TQ) system and the Agilent RapidFire 400 system at ASMS 2020 Reboot, the interactive, online version of the annual conference of the American Society for Mass Spectrometry.
The major components that make up a chromatography instruments are the columns, chambers, columns, and the chromatography analyzer. In the case of ion-based mass spectrometry, the semi-permanent column present in a chamber separates the analytes from the mobile contaminants. The mobile particles are picked by a spectrophotometer for quantitative separation.
There are several other techniques used in chromatography, such as experimental methods, non-experimental methods, ultra-fast method and ultra-sonic methods. Ultra-fast method involves use of chromatography instruments such as ultra-sonic beads to create short time columns. In the U.S., Liquid chromatography–mass spectrometry technique is used to test and analyze various biopharmaceutical products. For instance, in October 2019, the U.S. Food and Drug Administration (FDA) recommended pharmaceutical companies to use Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) for testing N-nitrosodimethylamine (NDMA) in ranitidine products. The NDMA is found to be carcinogenic in nature.
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